The Xulane transdermal system uses a 28-day (4-week) cycle. A new patch is applied each week for three weeks (21 total days). Week 4 is patch-free. Withdrawal bleeding is expected during this time.
Patch adhesion must be checked daily. Xulane must adhere securely to the skin to work properly. Women using Xulane have approximately 60% greater total ethinyl estradiol exposure compared with oral contraceptives containing 35 mcg of estrogen, which may increase risk of adverse events, including venous thromboembolism (VTE).
Before application, the patient should make sure her skin is clean and dry. Patients should not use lotions, creams, oils, powders, or makeup at the patch site. This may cause Xulane to fail to adhere properly or become loose. The patch should be placed where it won't be rubbed by tight clothing. Do not place on breasts, cut or irritated skin, or on the same location as the previous patch. The patient should check her patch every day to make sure all edges are sticking correctly. Xulane must adhere securely to the skin to work properly.
Xulane is indicated for the prevention of pregnancy in women with a body mass index (BMI) < 30 kg/m2 for whom a combined hormonal contraceptive is appropriate.
Xulane may be less effective in preventing pregnancy in women who weigh 198 lbs. (90 kg) or more. Xulane is contraindicated for use in women with BMI ≥ 30 kg/m2 [see Contraindications (4), Warnings and Precautions (5.1) and Clinical Studies (14)].
WARNING: CIGARETTE SMOKING AND SERIOUS CARDIOVASCULAR EVENTS and CONTRAINDICATED IN WOMEN WITH A BMI ≥ 30 kg/m2
Patients should be counseled that Xulane does not protect against HIV infection (AIDS) and other sexually transmitted infections.
This is not all of the information you should read prior to prescribing Xulane. Click here for Full Prescribing Information, including Boxed WARNING.
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